MILLION – Byri https://www.byri.net Automobile Industry News For Cars and Bikes Thu, 11 May 2023 13:49:03 +0000 en-US hourly 1 https://wordpress.org/?v=5.9.5 https://www.byri.net/wp-content/uploads/2023/02/cropped-letter-b-32x32.png MILLION – Byri https://www.byri.net 32 32 15 million Ukrainians after the war will need the help of a psychologist: the forecast of the Ministry of Health https://www.byri.net/2023/05/11/15-million-ukrainians-after-the-war-will-need-the-help-of-a-psychologist-the-forecast-of-the-ministry-of-health/ https://www.byri.net/2023/05/11/15-million-ukrainians-after-the-war-will-need-the-help-of-a-psychologist-the-forecast-of-the-ministry-of-health/#respond Thu, 11 May 2023 13:49:03 +0000 https://www.byri.net/2023/05/11/15-million-ukrainians-after-the-war-will-need-the-help-of-a-psychologist-the-forecast-of-the-ministry-of-health/

The director of the department of the Ministry of Health of Ukraine said that WHO, together with her department, trained about 10,000 specialists in the provision of primary psychological care. Also, Ukrainians can seek support from a family doctor.

After the end of the war with Russia, about 15 million citizens of Ukraine will need psychological help. This was announced on Thursday, May 11, by the director of the Department of Medical Services of the Ministry of Health, Alexandra Mashkevich, on the air of the national telethon “United News”.

According to Mashkevich, after the war in Ukraine, a wide variety of categories of the population will need psychological assistance, such as veterans, military personnel and their families, children and adolescents, Ukrainians who have been in captivity, and others.

“According to our tentative estimates, about 15 million citizens will need psychological assistance and psychosocial support,” a spokeswoman for the Ministry of Health said.

Psychological help during the war available now

Now, according to Mashkevich, about 10,000 primary care physicians have been trained in Ukraine, who have undergone specialized training from the WHO and the Ministry of Health to master the skills of primary psychological care and support.

The director of the department also noted that Ukrainians can apply for psychological assistance to their family doctor.

Recall, on March 16, it became known that the first full online platform began operating in Ukraine, where information is collected on all key services to help Ukrainians affected by the war.

We also recall that at the end of December 2022, a program of psychological training for the military was quietly launched in Ukraine to combat the fear, excitement and frustration experienced by the soldiers of the armed forces in the war against the Russian army.

]]>
https://www.byri.net/2023/05/11/15-million-ukrainians-after-the-war-will-need-the-help-of-a-psychologist-the-forecast-of-the-ministry-of-health/feed/ 0
An excellent station wagon 4×4 for 1.5 million rubles was named https://www.byri.net/2023/05/11/an-excellent-station-wagon-4x4-for-1-5-million-rubles-was-named/ https://www.byri.net/2023/05/11/an-excellent-station-wagon-4x4-for-1-5-million-rubles-was-named/#respond Thu, 11 May 2023 12:01:02 +0000 https://www.byri.net/2023/05/11/an-excellent-station-wagon-4x4-for-1-5-million-rubles-was-named/ The most massive combination of engine and gearbox has earned the model not the best reputation. But we found something that you will definitely like…

Behind the wheel

Among the variety of VAG cars on the market of all-wheel drive wagons with mileage, there are quite original options. Sergey Zinoviev, an expert behind the wheel, carefully studied this market and, in particular, dwelled in detail on the fourth generation Subaru Outback, which was produced from 2009 to 2014.

Do not rush to conclusions about reliability! Yes, the boxer aspirated 2.5 (167 hp) and the TR690 variator can cause a lot of problems already at 150 thousand mileage. But this is not the only combination, although the most common.

Behind the wheel

*This material was created by a person who has the status of a foreign agent in the Russian Federation.

There is also a top-end 3.6 (249 hp), which is friends with a 5-speed automatic, related to the Jatco JR507E. And although both units have minor ailments, but in terms of resource, this is a very hardy union – over 350 thousand km. It is worth focusing on this option.

Outback’s clearance would be quite suitable for an SUV (213 mm), permanent drive – with a torque distribution of 60:40, there is an imitation of wheel locks. The rear suspension uses complex self-leveling shock absorbers, which are replaced with conventional ones after death.

Trunk volume – 460 liters. And the equipment of the car is highly dependent on the level of equipment – the basic one, for example, is quite modest. But with the 3.6 engine, this does not threaten you. The price level for the fourth generation Subaru Outback: from 0.9 to 1.7 million rubles.

We are exploring five more excellent options for all-wheel drive station wagons with mileage.

“Driving” can be read in Viber

Photo: Subaru

_________________________

readmore can be: https://www.zr.ru/content/news/942762-nazvan-idealnyj-(polnoprivodn/

]]>
https://www.byri.net/2023/05/11/an-excellent-station-wagon-4x4-for-1-5-million-rubles-was-named/feed/ 0
Replacing the symbolism at the Motherland Monument will cost about UAH 36 million, experts say https://www.byri.net/2023/05/11/replacing-the-symbolism-at-the-motherland-monument-will-cost-about-uah-36-million-experts-say/ https://www.byri.net/2023/05/11/replacing-the-symbolism-at-the-motherland-monument-will-cost-about-uah-36-million-experts-say/#respond Thu, 11 May 2023 01:17:01 +0000 https://www.byri.net/2023/05/11/replacing-the-symbolism-at-the-motherland-monument-will-cost-about-uah-36-million-experts-say/

Ukrainian Institute of Steel Structures named after Shimanovsky was told when a trident will appear on the shield of the Motherland instead of the Soviet coat of arms.

The dismantling of the emblem of the USSR and the establishment of national Ukrainian symbols will cost about UAH 36 million. Oleksandr Shimanovsky, General Director of the Ukrainian Institute of Steel Structures named after V.I. Shimanovsky.

In February 2018, the TSN channel, citing experts, reported that the dismantling of the emblem of the USSR would cost UAH 500,000, and its replacement with other symbols would cost about UAH 8 million.

Meanwhile, Shimanovsky argues that today we are no longer talking about such amounts. According to him, the cost of producing design documentation for the repair of a lifting device [специального крана, который необходим для выполнения работ и находится внутри головы Родины-Матери] and the replacement of national symbols is UAH 2.5 million.

Construction and installation work in total will cost about UAH 36 million.

Nikolai Chernomyz, Deputy General Director for the manufacture and installation of metal structures of the Institute. Shimanovsky, in turn, explains that they have already signed an agreement with the institute for the preparation of design documentation for the repair of the lifting device. Specialists must complete it before July this year.

After that, the contractor must purchase equipment and materials and begin repair work.

“But now no one can say how long it will take them. Perhaps three months is the repair itself, and testing, and putting the crane into operation,” says the deputy general director.

If the whole process goes well and the crane is ready in the autumn, then the dismantling of the Soviet coat of arms and the establishment of Ukrainian national symbols will begin in late spring – early summer of next year. In cold seasons, such work is impossible – at a height of 92 meters it is simply dangerous. This requires warm weather without wind, explains Chernomyz.

In an ideal scenario, the decommunization of the Motherland should be completed by Independence Day 2024.

“They [Минкульт] they wanted to change everything by August 24 of this year, but the documents have not yet been approved,” the expert adds.

Recall, Minister of Culture and Information Policy Oleksandr Tkachenko said last week that in the Motherland they would replace the coat of arms of the USSR with a Ukrainian trident. According to Tkachenko, the Ministry is currently working on project documentation.

]]>
https://www.byri.net/2023/05/11/replacing-the-symbolism-at-the-motherland-monument-will-cost-about-uah-36-million-experts-say/feed/ 0
Four-story house for €6 million: property found in the Czech Republic at the family of the head of Russian missile production https://www.byri.net/2023/05/10/four-story-house-for-e6-million-property-found-in-the-czech-republic-at-the-family-of-the-head-of-russian-missile-production/ https://www.byri.net/2023/05/10/four-story-house-for-e6-million-property-found-in-the-czech-republic-at-the-family-of-the-head-of-russian-missile-production/#respond Wed, 10 May 2023 19:56:06 +0000 https://www.byri.net/2023/05/10/four-story-house-for-e6-million-property-found-in-the-czech-republic-at-the-family-of-the-head-of-russian-missile-production/ The authors of the investigation noted that Rostislav Zorikov, son-in-law of Boris Obnosov, also has a hobby – collecting expensive cars. At the same time, based on the declaration, his annual income does not exceed 447 thousand rubles.

The family of the head of the Russian defense holding Tactical Missiles, Boris Obnosov, who is under international sanctions, owns real estate in Europe. This is stated in the new investigation of the team of Alexei Navalny on May 10.

rockets, investigation, Czech Republic, real estate, sanctions, real estate in Prague, Boris Obnosov, Rostislav Zorikov

Fullscreen

Real estate is registered for the family of Boris Obnosov in Europe

Photo: Navalny’s team

The real estate of the family of Boris Obnosov, as the authors of the report note, is located in the Czech capital – Prague. Its total cost is not less than 8 million euros. The son-in-law of the head of the defense enterprise, Rostislav Zorikov, received a four-story house in the historical center of Prague for 6 million euros, as evidenced by the data that is in the cadastral extract.

rockets, investigation, Czech Republic, real estate, sanctions, real estate in Prague, Boris Obnosov, Rostislav Zorikov

Fullscreen

Real estate is registered for the family of Boris Obnosov in Europe

Photo: Navalny’s team

rockets, investigation, Czech Republic, real estate, sanctions, real estate in Prague, Boris Obnosov, Rostislav Zorikov

Fullscreen

Real estate is registered for the family of Boris Obnosov in Europe

Photo: Navalny’s team

Separately, emphasis is placed on the fact that in 2020 Rostislav Zorikov earned 447,000 rubles, that is, 37,000 per month. At the same time, he has real estate in the Czech Republic and an unusual hobby for such a standard of living – collecting expensive cars. With an income of less than half a million rubles a year, the following vehicles were recorded on him: Jaguar F-PACE, Lamborghini Aventador, Rolls-Royce Phantom, Packard and many others.

rockets, investigation, Czech Republic, real estate, sanctions, real estate in Prague, Boris Obnosov, Rostislav Zorikov

Fullscreen

Real estate is registered for the family of Boris Obnosov in Europe

Photo: Navalny’s team

Other relatives of Boris Obnosov recorded four more apartments.

Maria Pevchikh, Chairman of the Board of Directors of the Anti-Corruption Foundation, in connection with the information that has appeared, called on the Czech authorities to ban Boris Obnosov and the Zorikov family, who own the property, from entering the country.

“Their head of the family is a real war criminal, the Tactical Missiles Corporation is a participant in the war in Ukraine. We will complain wherever we can, we will write to all Czech departments, to the police and the Foreign Ministry, and we will demand personal sanctions against the Zorikovs, Obnosovs and all the firms they have here,” the statement said.

Recall, on May 4, it was reported that businessman Gennady Timchenko, who is associated with Putin, is trying to challenge personal sanctions. His lawyer Stephane Bonifassi has already stated that his client’s friendly ties with Russian President Vladimir Putin “do not make him an ally in the war with Ukraine.”

]]>
https://www.byri.net/2023/05/10/four-story-house-for-e6-million-property-found-in-the-czech-republic-at-the-family-of-the-head-of-russian-missile-production/feed/ 0
The average price of a car approached 2.5 million rubles https://www.byri.net/2023/05/10/the-average-price-of-a-car-approached-2-5-million-rubles/ https://www.byri.net/2023/05/10/the-average-price-of-a-car-approached-2-5-million-rubles/#respond Wed, 10 May 2023 06:25:05 +0000 https://www.byri.net/2023/05/10/the-average-price-of-a-car-approached-2-5-million-rubles/ And this is with an average salary in the country of 53 thousand rubles.

Behind the wheel

According to the results of the first quarter of 2023, the weighted average price of a new passenger car in Russia amounted to 2.478 million rubles, the analytical agency ASM-Holding calculated. At the same time, according to Avito Rabota, the average salary in Russia in January-March amounted to 53,096 thousand rubles per month.

But even for 2.5 million rubles, as it turned out, the choice of cars is not too great. Among Russian cars, you can meet this amount when buying Lada models, as well as gasoline Moskvich 3, among foreign cars these are only Chinese crossovers: Geely Coolray, Bestune T77, Chery Tiggo 4 Pro.

In Russia today you can also buy models made in China together with enterprises from Europe, South Korea and Japan: Jetta VS5, Hyundai Bayon and Mitsubishi Xpander, as well as Volkswagen Lavida Qihang and Volkswagen Polo.

“Driving” can now be viewed on RuTube.

Source: based on media materials

Photo: Sergey Konkov/TASS

]]>
https://www.byri.net/2023/05/10/the-average-price-of-a-car-approached-2-5-million-rubles/feed/ 0
Horror from the bottom of the ocean. Scientists have resurrected the appearance of an ancient monster that lived on Earth 300 million years ago https://www.byri.net/2023/05/09/horror-from-the-bottom-of-the-ocean-scientists-have-resurrected-the-appearance-of-an-ancient-monster-that-lived-on-earth-300-million-years-ago/ https://www.byri.net/2023/05/09/horror-from-the-bottom-of-the-ocean-scientists-have-resurrected-the-appearance-of-an-ancient-monster-that-lived-on-earth-300-million-years-ago/#respond Tue, 09 May 2023 08:44:19 +0000 https://www.byri.net/2023/05/09/horror-from-the-bottom-of-the-ocean-scientists-have-resurrected-the-appearance-of-an-ancient-monster-that-lived-on-earth-300-million-years-ago/ The massive, furious creature roamed the ancient Scottish swamps over 300 million years ago, with a three-meter-long body, massive teeth and large eyes. This creature is Crassigyrinus scoticus, a crocodile-like predator that hunted its prey with ruthless efficiency.

Advances in computed tomography and 3D imaging have enabled researchers to reconstruct the skull of Crassigyrinus Scoticus for the first time, shedding new light on the appearance and behavior of the ancient predator. As an early tetrapod, Crassigyrinus was a huge aquatic predator that lived in the coal marshes of Scotland and parts of North America during the Lower and Middle Carboniferous, writes IFLScience.

Focus.Technology has its own Telegram channel. Subscribe to not miss the latest and exciting news from the world of science!

Although closely related to some of the first species to make the transition from water to land, Crassigyrinus itself never landed on it.

For almost a century, scientists have been studying the remains of this aquatic animal. However, their progress was hampered by the fact that all known fossils were severely crushed due to being preserved in fine-grained rock. This led to the fact that many broken and deformed bones, with fragments lying randomly on top of each other, made it very difficult for researchers to restore their appearance.

But now, thanks to advances in computed tomography (CT) and 3D imaging, the team has been able to digitally reconstruct the skull of Crassigyrinus for the first time. Using pieces from four samples of all the skull bones, they were able to put the pieces together like a 3D puzzle.

ancient animals, monster, existence, research, paleontology, Crassigyrinus scoticus, ancient Scottish predator, tetrapod evolution, computed tomography, 3D reconstruction, biomechanical modeling, professor Jenny Kluck, dinosaurs, extinct predator

Fullscreen

Thanks to advances in computed tomography (CT) and 3D imaging, the team was able to digitally reconstruct the skull of Crassigyrinus for the first time.

Фото: Porro et al., Journal of Vertebrate Paleontology, 2023 (CC BY 4.0)

Dr Laura Porro of University College London, lead author of the study, found that the animal had a skull similar to that of modern crocodiles, with large teeth and powerful jaws.

Thanks to them, they could devour everything that happened on the way. Combined with recent body studies, this suggests that the animal was rather splashy with short limbs, allowing it to hide below the surface of the water and grab prey with a powerful bite, similar to modern crocodiles.

The reconstructed skull also showed that Crassigyrinus had specialized sensory organs that helped it track prey, including large eyes. Thanks to them, he could see in the darkness of the coal marshes, as well as lateral lines that detected vibrations in the water.

There is also an amazing gap in the front of the skull, which may have given it other senses as well. One theory is that this gap may have contained a rostral organ that allowed Crassigyrinus to detect electric fields, or an early example of Jacobson’s organ that allowed him to distinguish between various chemicals. However, whatever was in this gap, it was not preserved and remains a mystery.

The study is dedicated to co-author Professor Jenny Kluck, a pioneering paleontologist who revolutionized our understanding of early tetrapod evolution and died in 2020. The new reconstructions are now being used to experiment with a series of biomechanical simulations to see what this terrifying predator was really capable of.

Focus previously wrote about a new discovery that rewrites dinosaur history. It turns out they walked the Earth millions of years earlier.

We also talked about a 180-million-year-old fossil: how the remains of ancient marine reptiles have survived to this day.

]]>
https://www.byri.net/2023/05/09/horror-from-the-bottom-of-the-ocean-scientists-have-resurrected-the-appearance-of-an-ancient-monster-that-lived-on-earth-300-million-years-ago/feed/ 0
Almost 2 million years ago. Scientists discover when human cancer first appeared https://www.byri.net/2023/05/08/almost-2-million-years-ago-scientists-discover-when-human-cancer-first-appeared/ https://www.byri.net/2023/05/08/almost-2-million-years-ago-scientists-discover-when-human-cancer-first-appeared/#respond Mon, 08 May 2023 12:24:31 +0000 https://www.byri.net/2023/05/08/almost-2-million-years-ago-scientists-discover-when-human-cancer-first-appeared/ Cancer may seem like a modern disease, but it has been affecting people for centuries. The first case is thought to be cancer in the big toe bone of an ancient human relative.

Scientists have discovered numerous prehistoric remains of people indicating the presence of cancer. In addition, the researchers found the first mention of this deadly disease in ancient written sources, writes Live Science.

Focus.Technology has its own Telegram channel. Subscribe to not miss the latest and exciting news from the world of science!

It is believed that the first evidence of cancer is 1.7 million years old. This man, who suffered from it, probably belonged to the species Paranthropus robustus or Homo ergaster, lived with a malignant tumor in the bone of his left toe.

Archaeologists have discovered the remains in Swartkrans Cave, a limestone deposit in South Africa. There is the largest concentration of skeletons of ancient people and their close relatives.

When researchers compared computed tomography (CT) scans of a fossilized toe bone with images of modern cases of osteosarcoma, an aggressive form of cancer that begins in bone-forming cells, they immediately recognized the characteristic cauliflower-like appearance of osteosarcoma.

Today, osteosarcoma is a very common type of bone cancer in humans that can occur at any age, although it is most commonly seen in children, adolescents, and young adults. However, although the age of this prehistoric man is unknown, it looks like he was an adult, the researchers say.

It is understandable that the oldest known case of cancer was found in bones, since organs, skin and other soft tissues are much more susceptible to decay than bones.

However, even if cancer is present in the fossil, it is not easy to see with the naked eye, and therefore further detailed studies are important.

The oldest references to cancer

ancient people, cancer, disease, first case of cancer, research, archeology, excavations, history

Fullscreen

The Edwin Smith Papyrus is an ancient Egyptian manuscript dating from the 16th century BC. e., having texts of a medical nature, in particular on surgery

In 3000 BC, Imhotep, an ancient Egyptian mathematician, physician, and architect, wrote what became known as the Edwin Smith Papyrus, a textbook on bodily injury and surgical procedures. In the text, he detailed 48 medical cases, including several cases of breast cancer.

The manuscript is written in hieratic script, which was used in ancient Egypt in parallel with hieroglyphic script, especially for secular documents of an administrative, commercial, and legal nature. It was subsequently translated into English by the American archaeologist James Henry Breasted.

An ancient physician described the characteristics of different types of tumors, in particular the breast. In addition, he gives several examples of treatment. Unfortunately, in the “therapy” section of a breast tumor, he wrote: “does not exist.”

However, he noted better treatments for other types of tumors, which included making an ointment from fat, honey, and lint.

Researchers find it difficult to answer exactly how these cases of prehistoric cancer developed. Like the people who lived before us, we are still trying to figure out what this disease is and how best to treat it.

Previously, Focus talked about how the Romans treated the sick. They used “urinary flasks” to sniff and taste urine.

We also wrote about 10 popular myths about skin cancer that scientists have debunked. In particular, makeup will not protect the skin, and melanoma is not just a mole that needs to be removed.

]]>
https://www.byri.net/2023/05/08/almost-2-million-years-ago-scientists-discover-when-human-cancer-first-appeared/feed/ 0
Erdogan “greeted every street”: about 1.7 million people came to the rally in Istanbul (video) https://www.byri.net/2023/05/07/erdogan-greeted-every-street-about-1-7-million-people-came-to-the-rally-in-istanbul-video/ https://www.byri.net/2023/05/07/erdogan-greeted-every-street-about-1-7-million-people-came-to-the-rally-in-istanbul-video/#respond Sun, 07 May 2023 19:36:02 +0000 https://www.byri.net/2023/05/07/erdogan-greeted-every-street-about-1-7-million-people-came-to-the-rally-in-istanbul-video/ At a campaign event, the Turkish president promised that he would not allow the opposition to divide the country. The politician accompanied the video from the rally in his support with a song, the title of which translates as “There is no other Erdogan.”

Turkish President Recep Tayyip Erdogan held an election rally in Istanbul on May 7, which was attended by about 1.7 million people. He said this during a speech to the audience, the newspaper Habertürk writes.

“We love Istanbul very much. We walked from here to the presidency, now we are on the road with you again. Now I have been given official figures – 1 million 700 thousand people have come. Istanbul, I welcome every street, quarter and hill. As the poet says, if we do not love Istanbul, what the heart understands about love,” he said in a campaign speech.

The head of state published the video of the event in his Telegram. A song is played in the background, the title of which translates as “There is no other Erdogan.”

According to the current president, the people will give an answer on May 14, on the day of voting for the future leader of the country.

“We will not divide our country. We will not allow Kemal Kılıçdaroglu (leader of the Republican People’s Party of Turkey, Erdogan’s main opponent in the elections – ed.), traveling with terrorist organizations, to divide the country,” Erdogan added.

Rally in support of Erdogan, Erdogan, Recep Tayyip Erdogan at a rally, rally istanbul

Fullscreen

A rally in support of Erdogan was held in the National Garden of Ataturk Airport

Fullscreen

Son Dakika specifies that the rally was held in the National Garden of Ataturk Airport. Erdogan took the stage with his wife Emine.

Turkish presidential elections due on May 14

Recall that on April 26, the media reported on a possible heart attack in Recep Tayyip Erdogan live. The broadcast on Ülke TV was interrupted after the Turkish leader became ill.

Erdogan’s representatives denied these rumors and called the news disinformation. And on April 27, the Turkish president spoke with Russian President Vladimir Putin by phone.

The Presidents discussed the construction of the Akkuyu nuclear power plant in Turkey.

]]>
https://www.byri.net/2023/05/07/erdogan-greeted-every-street-about-1-7-million-people-came-to-the-rally-in-istanbul-video/feed/ 0
A random event 1 million years ago changed the brain forever: the secret of DNA sections is revealed https://www.byri.net/2023/05/07/a-random-event-1-million-years-ago-changed-the-brain-forever-the-secret-of-dna-sections-is-revealed/ https://www.byri.net/2023/05/07/a-random-event-1-million-years-ago-changed-the-brain-forever-the-secret-of-dna-sections-is-revealed/#respond Sun, 07 May 2023 11:17:07 +0000 https://www.byri.net/2023/05/07/a-random-event-1-million-years-ago-changed-the-brain-forever-the-secret-of-dna-sections-is-revealed/

Like family recipes that are passed down from generation to generation, there are certain sections of DNA that remain unchanged throughout evolution.

Mammals around the world have many unchanging coded sequences that remain intact for millions of years. Humans, however, are a strange exception to this pattern. For some reason, the “recipes” preserved by our ancient ancestors suddenly changed during a short evolutionary period, writes ScienceAlert.

Focus.Technology has its own Telegram channel. Subscribe to not miss the latest and exciting news from the world of science!

These regions of human DNA that have undergone rapid changes are known as “Human Developmental Accelerated Zones” (HARs). Scientists believe that at least some of these HARs may be responsible for the unique qualities that distinguish humans from their closest relatives such as chimpanzees and bonobos.

A team of researchers identified HARs almost two decades ago when comparing human and chimpanzee genomes. In a recent study, the team found that the three-dimensional folding of human DNA in the nucleus is a critical factor at this pivotal moment for our species.

To understand how these changes in human DNA came about, imagine a long scarf from the DNA of our last common ancestor with chimpanzees wrapped around your neck. Stripes of different colors run along its entire length.

Now imagine that someone is trying to make exactly the same scarf, but not quite the original pattern. Some stripes are narrower, some are wider, and some colors are in a different order than the original. When you wrap the new scarf around your neck in the same way as the original, the strips next to each other in the loop will no longer be the same.

Similarly, the essential difference between human and chimpanzee DNA is structural. Large pieces of the building blocks of DNA have been inserted, removed or rearranged in the human genome, causing human DNA to fold differently in the nucleus than other primate DNA.

The team investigated whether these structural changes in human DNA and its altered 3D folding could lead to certain genes being “captured” into HARs, linking them to different protein-coding genes than the ones they were originally attached to. Many genes within HARs are enhancers, that is, they increase the transcription of their associated gene/genes.

In their latest study, the team compared the genomes of 241 mammalian species using machine learning to analyze vast amounts of data. They identified 312 HARs and studied where they are located in the three-dimensional “neighbourhood” of folded DNA.

Nearly 30 percent of the HARs were located in areas of DNA where structural variations caused the human genome to fold differently from other primates.

The team also found that regions containing HARs are rich in genes that distinguish humans from our closest relatives, chimpanzees. In an experiment comparing DNA in growing human and chimpanzee stem cells, one third of the identified HARs were transcribed during the development of the human neocortex.

Many HARs play a role in embryonic development, especially in the formation of neural pathways associated with intelligence, reading, social skills, memory, attention, and focus, traits that are markedly different in humans from other animals. In HARs, these enhancer genes, unchanged for millions of years, may have had to adapt to their different target genes and regulatory domains.

Such dramatic changes in genome architecture could have profound implications for gene regulation and cellular function, which could help explain the extraordinary variety of traits that distinguish us from other primates.

The team is now studying how specific HARs contribute to the evolution of the human brain and how they interact with other genetic and environmental factors to shape individual differences in cognition and mental health.

Their ultimate goal is to shed light on the genetic basis of human uniqueness and to identify potential targets for therapeutic intervention in neuropsychiatric disorders thought to arise from the downregulation of gene networks involved in brain development and function.

Focus previously wrote about a promising new drug to combat symptoms. Atogepant was safe, well tolerated and effective in the treatment of migraine.

We also talked about what can save you from aging and dementia. Scientists associate a decrease in muscle strength with signs of illness.

]]>
https://www.byri.net/2023/05/07/a-random-event-1-million-years-ago-changed-the-brain-forever-the-secret-of-dna-sections-is-revealed/feed/ 0
Rudkovskaya boasted a new car for 30 million rubles https://www.byri.net/2023/05/07/rudkovskaya-boasted-a-new-car-for-30-million-rubles/ https://www.byri.net/2023/05/07/rudkovskaya-boasted-a-new-car-for-30-million-rubles/#respond Sun, 07 May 2023 07:05:06 +0000 https://www.byri.net/2023/05/07/rudkovskaya-boasted-a-new-car-for-30-million-rubles/ The producer admitted that she worked hard to fulfill her dream.

Behind the wheel

Public figures for the most part try not to shine their expensive purchases. Especially now, when the tax authorities have taken seriously millionaire bloggers.

But producer Yana Rudkovskaya believes that she has nothing to hide, and demonstrates the attributes of a luxurious life.

The other day she boasted that her dream came true and she became the owner of a luxury car Mercedes-Maybach GLS 600.

Behind the wheel

“A long-awaited dream come true, for which I worked very hard,” Yana wrote, showing a photo of a car tied with a red ribbon. And added: “All taxes paid!”

According to experts, the purchase cost Rudkovskaya at least 30 million rubles. And taking into account the options, it could cost all 40 million.

“Driving” can be read in Odnoklassniki

Source: social media

Photo: social networks of the hero of the publication

]]>
https://www.byri.net/2023/05/07/rudkovskaya-boasted-a-new-car-for-30-million-rubles/feed/ 0